Hydrochloric Acid → 2-Amino-1-(morpholin-4-yl)ethan-1-one--hydrogen chloride (1/1)

HRID 1814740Notes

Reaction equation

HRID 1814740 reaction equation
C(OC(=O)[NH:7][CH2:8][C:9]([N:11]1[CH2:16][CH2:15][O:14][CH2:13][CH2:12]1)=[O:10])(C)(C)C.[ClH:18]>O1CCOCC1>[ClH:18].[NH2:7][CH2:8][C:9]([N:11]1[CH2:16][CH2:15][O:14][CH2:13][CH2:12]1)=[O:10]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 10538259tert-Butyl [2-(morpholin-4-yl)-2-oxoethyl]carbamate

Product 1

HCID 122918142-Amino-1-(morpholin-4-yl)ethan-1-one--hydrogen chloride (1/1)Yield 76%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

To a stirred solution of the above (2-morpholin-4-yl-2-oxo-ethyl)-carbamic acid tert-butyl ester (0.44 g, 1.8 mmol) in 1,4-dioxane (4.0 mL), HCl (4.0 mL of a 4 M solution in 1,4-dioxane) was added at room temperature. After one h, the precipitated product was collected via filtration and washed with EtOAc. The solid was dried under high vacuum to give 0.23 g (76%) of 2-amino-1-morpholin-4-yl-ethanone hydrochloride which was used without further purification.

Workup

  1. filtrationAfter one h, the precipitated product was collected via filtration
  2. washwashed with EtOAc
  3. customThe solid was dried under high vacuum

Sources & evidence

ORD record
ord-83fba8d2fdac469082f67417fadf52a3
Source dataset
uspto-grants-2005_04
Patent number
US06878706B1

Reaction notes

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