Dichloromethane → 1-(2,2,2-trifluoro-acetyl)-pyrrolidine-2-carboxylic Acid {2-dimethylcarbamoyl-6-fluoro-4-[3-(2-methoxy-phenyl)-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-phenyl}-amide

HRID 181476노트

반응식

[CH:41]([N:42]([CH2:43][CH3:44])[CH:45]([CH3:46])[CH3:47])([CH3:48])[CH3:49].[Cl:64][CH2:65][Cl:66].[F:50][C:51]([C:52](=[O:53])[N:54]1[CH:55]([C:56](=[O:57])[Cl:58])[CH2:59][CH2:60][CH2:61]1)([F:62])[F:63].[NH2:1][c:2]1[c:3]([C:4](=[O:5])[N:6]([CH3:7])[CH3:8])[cH:9][c:10](-[c:14]2[cH:15][c:16]3[c:17]([n:18][cH:19]2)[n:20]([S:31](=[O:32])(=[O:33])[c:34]2[cH:35][cH:36][c:37]([CH3:40])[cH:38][cH:39]2)[cH:21][c:22]3-[c:23]2[c:24]([O:29][CH3:30])[cH:25][cH:26][cH:27][cH:28]2)[cH:11][c:12]1[F:13]>>[NH:1]([c:2]1[c:3]([C:4](=[O:5])[N:6]([CH3:7])[CH3:8])[cH:9][c:10](-[c:14]2[cH:15][c:16]3[c:17]([n:18][cH:19]2)[n:20]([S:31](=[O:32])(=[O:33])[c:34]2[cH:35][cH:36][c:37]([CH3:40])[cH:38][cH:39]2)[cH:21][c:22]3-[c:23]2[c:24]([O:29][CH3:30])[cH:25][cH:26][cH:27][cH:28]2)[cH:11][c:12]1[F:13])[C:56]([CH:55]1[N:54]([C:52]([C:51]([F:50])([F:62])[F:63])=[O:53])[CH2:61][CH2:60][CH2:59]1)=[O:57]