Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | L-Phenylalanine | HCID 6140 | — |
| Reactant | Acetyl chloride | HCID 6367 | — |
| Reactant | HCID 13048322 | HCID 13048322 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 20772337 | HCID 20772337 | — |
Reaction Steps
The alcohol, (1-hydroxy-indan-2-yl)-carbamic acid methyl ester (1S-trans) prepared from L-phenylalanine (18.7 g, 0.09 mol) (J. Org. Chem. 1983, 48, 2675-2679) is suspended in methylene chloride and cooled to 0° C. Pyridine (10.7 g, 0.135 mol) is added followed by acetyl chloride (10.5 g, 0.135 mol). The mixture is stirred for 1 h, and then washed with sodium bicarbonate, 1N HCl and saturated sodium chloride. The organic layer is dried over Na2SO4, filtered and evaporated under reduced pressure to give (1-acetyloxy-indan-2-yl)-carbamic acid methyl ester (1S-trans).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06878707B2 |
|---|
| Source dataset | uspto-grants-2005_04 |
|---|
| ORD ID | ord-73f024b25d364e2389fcb26b9a28a8bd |
|---|
| Source note | uspto-grants-2005_04 |
|---|
