Methyl 2-(4-trifluoromethylbenzyloxy)-3-methylbenzoate → 2-(4-trifluoromethylbenzyloxy)-3-methylbenzoic Acid

Beteiligte Stoffe

Reaktionsschritte

To a solution of methyl 2-(4-trifluoromethylbenzyloxy)-3-methylbenzoate (1.17 g, 3.61 mmol) is added 10 mL of 1N LiOH. The mixture is stirred at room temperature for 3 days, then concentrated under vacuum. The residue is washed with hexane, then acidified to pH 1 with 6N HCl. A white precipitate forms which is extracted with ethyl acetate. The organic solution is dried over sodium sulfate, filtered and concentrated to give the title acid as a white solid, m.p. 104-106° C.

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