Methyl 2-(4-trifluoromethylbenzyloxy)-3-methylbenzoate → 2-(4-trifluoromethylbenzyloxy)-3-methylbenzoic Acid

HRID 1814789Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1814789
[F:1][C:2]([F:23])([F:22])[C:3]1[CH:21]=[CH:20][C:6]([CH2:7][O:8][C:9]2[C:18]([CH3:19])=[CH:17][CH:16]=[CH:15][C:10]=2[C:11]([O:13]C)=[O:12])=[CH:5][CH:4]=1>[Li+].[OH-]>[F:1][C:2]([F:22])([F:23])[C:3]1[CH:21]=[CH:20][C:6]([CH2:7][O:8][C:9]2[C:18]([CH3:19])=[CH:17][CH:16]=[CH:15][C:10]=2[C:11]([OH:13])=[O:12])=[CH:5][CH:4]=1

Komponenten

3

Edukt 1

HCID 22498800Methyl 2-(4-trifluoromethylbenzyloxy)-3-methylbenzoate

Produkt 1

HCID 224987992-(4-trifluoromethylbenzyloxy)-3-methylbenzoic Acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3939Lithium HydroxideLösungsmittel

Versuchsvorschrift

To a solution of methyl 2-(4-trifluoromethylbenzyloxy)-3-methylbenzoate (1.17 g, 3.61 mmol) is added 10 mL of 1N LiOH. The mixture is stirred at room temperature for 3 days, then concentrated under vacuum. The residue is washed with hexane, then acidified to pH 1 with 6N HCl. A white precipitate forms which is extracted with ethyl acetate. The organic solution is dried over sodium sulfate, filtered and concentrated to give the title acid as a white solid, m.p. 104-106° C.

Aufarbeitung

  1. concentrationconcentrated under vacuum
  2. washThe residue is washed with hexane
  3. extractionA white precipitate forms which is extracted with ethyl acetate
  4. dry with materialThe organic solution is dried over sodium sulfate
  5. filtrationfiltered
  6. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-d20e3f29b75e47d3abc218e1bc38ad54
Quelldatensatz
uspto-grants-2005_04
Patentnummer
US06878707B2

Notizen zur Reaktion

Wird geladen…