反应详情

To a solution of methyl 2-(4-trifluoromethylbenzyloxy)-3-methylbenzoate (1.17 g, 3.61 mmol) is added 10 mL of 1N LiOH. The mixture is stirred at room temperature for 3 days, then concentrated under vacuum. The residue is washed with hexane, then acidified to pH 1 with 6N HCl. A white precipitate forms which is extracted with ethyl acetate. The organic solution is dried over sodium sulfate, filtered and concentrated to give the title acid as a white solid, m.p. 104-106° C.

1. concentrationconcentrated under vacuum
2. washThe residue is washed with hexane
3. extractionA white precipitate forms which is extracted with ethyl acetate
4. dry with materialThe organic solution is dried over sodium sulfate
5. filtrationfiltered
6. concentrationconcentrated