Sodium Carbonate → HCID 22498801, compound

HRID 1814791Notes

Reaction equation

HRID 1814791 reaction equation
[CH:1]1[C:6]2[CH2:7][CH2:8][C:9](=O)[CH2:10][CH2:11][C:5]=2[CH:4]=[CH:3][CH:2]=1.Cl.[NH2:14][OH:15].C(=O)([O-])[O-].[Na+].[Na+]>O>[OH:15][NH:14][CH:9]1[CH2:8][CH2:7][C:6]2[CH:1]=[CH:2][CH:3]=[CH:4][C:5]=2[CH2:11][CH2:10]1

Participants

5

Reactant 3

HCID 10340Sodium CarbonateHCID 443297Hydroxyamine hydrochlorideHCID 122344855,6,8,9-Tetrahydro-7H-benzo[7]annulen-7-one

Product 1

HCID 22498801HCID 22498801, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

To 6,7,8,9-Tetrahydro-5H-benzocyclohepten-7-one (2.56 g, 16 mmol) and hydroxylamine hydrochloride (2.2 g, 32 mmol) in 27 mL of water is slowly added a solution of sodium carbonate (1.69 g, 16 mmol) in 14 mL of water. The mixture is stirred overnight. The solid is then filtered off, washed with water, and dried at 50° C. under reduced pressure to give 6,7,8,9-tetrahydro-N-hydroxy-5H-benzocyclohepten-7-amine as a white solid.

Workup

  1. filtrationThe solid is then filtered off
  2. washwashed with water
  3. customdried at 50° C. under reduced pressure

Sources & evidence

ORD record
ord-177c2c6e00c74a80b3cd7e25bc35b465
Source dataset
uspto-grants-2005_04
Patent number
US06878707B2

Reaction notes

Loading…