1-Benzyl-4-(N-Boc-amino)piperidine → 4-(N-Boc-amino)piperidine

HRID 1814810Notes

Reaction equation

HRID 1814810 reaction equation
C([N:8]1[CH2:13][CH2:12][CH:11]([NH:14][C:15]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16])[CH2:10][CH2:9]1)C1C=CC=CC=1>C(O)C.[Pd]>[C:18]([O:17][C:15]([NH:14][CH:11]1[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1)=[O:16])([CH3:21])([CH3:19])[CH3:20]

Participants

4

Reactant 1

HCID 44386181-Benzyl-4-(N-Boc-amino)piperidine

Product 1

HCID 7238334-(N-Boc-amino)piperidineYield 95.2%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 23938PalladiumSolvent

Procedure

1-Benzyl-4-t-butyloxycarbonylaminopiperidine (Method D, 5.4 g, 18.6 mmol) was dissolved in absolute ethanol (100 ml) and hydrogenated over 10% Pd/C for 24 hours at ambient temperature. The catalyst was removed by filtration and the filtrates evaporated to give the title compound (3.54 g, 17.7 mmol) which was used without further purification.

Workup

  1. customThe catalyst was removed by filtration
  2. customthe filtrates evaporated

Sources & evidence

ORD record
ord-e4e21712af8b4dd390e165f5b87dea96
Source dataset
uspto-grants-2005_04
Patent number
US06878712B1

Reaction notes

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