1-Benzyl-4-(N-Boc-amino)piperidine → 4-(N-Boc-amino)piperidine

Participants

Reaction Steps

1-Benzyl-4-t-butyloxycarbonylaminopiperidine (Method D, 5.4 g, 18.6 mmol) was dissolved in absolute ethanol (100 ml) and hydrogenated over 10% Pd/C for 24 hours at ambient temperature. The catalyst was removed by filtration and the filtrates evaporated to give the title compound (3.54 g, 17.7 mmol) which was used without further purification.

Provenance & Evidence