Chloroform → 2-Propyloxybenzamidine Hydrochloride

Temperature

2.5 °C

21.41 g (400 ml) of ammonium chloride are suspended in 400 ml of toluene and cooled to 0-5° C. 200 ml of a 2 M solution of trimethylaluminum in hexane are added dropwise, and the mixture is stirred at room temperature until the evolution of gas has ceased. Following addition of 32.2 g (200 mmol) of 2-propoxybenzonitrile, the reaction mixture is stirred at 80° C. (bath) overnight. The cooled reaction mixture is, with ice-cooling, added to a suspension of 300 g of silica gel and 2.85 ml of ice-cooled chloroform and stirred for 30 minutes. The mixture is filtered off with suction and the filter cake is washed with the same amount of methanol. The solvent is distilled off under reduced pressure, the residue is triturated in 500 ml of a mixture of dichloromethane and methanol (9:1), the solid is filtered off and the mother liquor is concentrated. The residue is triturated with petroleum ether and filtered off with suction. This gives 22.3 g (52%) of product.

1. stirringthe reaction mixture is stirred at 80° C. (bath) overnight
2. customThe cooled reaction mixture
3. temperaturecooling
4. stirringstirred for 30 minutes
5. filtrationThe mixture is filtered off with suction
6. washthe filter cake is washed with the same amount of methanol
7. distillationThe solvent is distilled off under reduced pressure
8. customthe residue is triturated in 500 ml of a mixture of dichloromethane and methanol (9:1)
9. filtrationthe solid is filtered off
10. concentrationthe mother liquor is concentrated
11. customThe residue is triturated with petroleum ether
12. filtrationfiltered off with suction

ORD record

ord-75b2d88c72cc4cf0863b019e741bb582

Source dataset

uspto-grants-2005_04

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06878708B2