HRID1814847

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID2733374

4-Fluorobenzenesulfonyl isocyanate

C7H4FNO3S

结构：CCCOc1ccc(N)cc1-c1nn2c(C3CCCC3)nc(C)c2c(=O)[nH]1

HCID135604925

未命名化合物

PRODUCTS

生成物

结构：CCCOc1ccc(NC(=O)NS(=O)(=O)c2ccc(F)cc2)cc1-c1nn2c(C3CCCC3)nc(C)c2c(=O)[nH]1

HCID135604954

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID8028

Tetrahydrofuran

C4H8O

PROCEDURE

实验过程

The preparation is carried out analogously to the procedure of example 54 using 150 mg (0.408 mmol) of the amino compound from example 44A and 411 mg (2.04 mmol) of 4-fluorobenzenesulfonyl isocyanate in 12 ml of tetrahydrofuran, which are reacted overnight.

WORKUP

后处理

customare reacted overnight

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-3639cad215a948be9cb779ef67db7bac
来源数据集: uspto-grants-2005_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06878708B2
来源说明: uspto-grants-2005_04

反应 SMILES

[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([O:24][CH2:25][CH2:26][CH3:27])=[C:6]([C:8]2[NH:13][C:12](=[O:14])[C:11]3=[C:15]([CH3:23])[N:16]=[C:17]([CH:18]4[CH2:22][CH2:21][CH2:20][CH2:19]4)[N:10]3[N:9]=2)[CH:7]=1.[F:28][C:29]1[CH:34]=[CH:33][C:32]([S:35]([N:38]=[C:39]=[O:40])(=[O:37])=[O:36])=[CH:31][CH:30]=1>O1CCCC1>[CH:18]1([C:17]2[N:10]3[C:11]([C:12](=[O:14])[NH:13][C:8]([C:6]4[CH:7]=[C:2]([NH:1][C:39]([NH:38][S:35]([C:32]5[CH:33]=[CH:34][C:29]([F:28])=[CH:30][CH:31]=5)(=[O:36])=[O:37])=[O:40])[CH:3]=[CH:4][C:5]=4[O:24][CH2:25][CH2:26][CH3:27])=[N:9]3)=[C:15]([CH3:23])[N:16]=2)[CH2:22][CH2:21][CH2:20][CH2:19]1