Piperidine → 4-Quinolone-3-carboxylic acid

HRID 1814849Notes

Reaction equation

HRID 1814849 reaction equation
N[C:2]1[C:11](F)=[C:10](F)[C:9](OC)=[C:8]2[C:3]=1[C:4](=[O:22])[C:5]([C:19]([OH:21])=[O:20])=[CH:6][N:7]2C1CC1.N1CCCCC1>>[O:22]=[C:4]1[C:3]2[C:8](=[CH:9][CH:10]=[CH:11][CH:2]=2)[NH:7][CH:6]=[C:5]1[C:19]([OH:21])=[O:20]

Participants

3

Reactant 2

HCID 8082PiperidineHCID 105668945-Amino-1-cyclopropyl-6,7-difluoro-8-methoxy-1,4-dihydro-4-oxoquinoline-3-carboxylic acid

Product 1

HCID 2208754-Quinolone-3-carboxylic acid

Procedure

5-Amino-1-cyclopropyl-6-fluoro-8-methoxy-7-{(4-amino/substituted amino/disubstituted amino/hydroxy-3-alkyl/3,3-dialkyl/3,5-dialkyl/3,3,5-trialkyl)1-1-piperidinyl)-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid and isomers were prepared by a procedure described in Method 1 by using 5-amino-1-cyclopropyl-6,7-difluoro-8-methoxy-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid and appropriate {4-(amino/substituted amino/disubstituted amino/hydroxy-3-alkyl/3,3-dialkyl/3,5-dialkyl/3,3,5-trialkyl)}piperidine.

Sources & evidence

ORD record
ord-09eec06cfbd74f07ada3c7c9b66def3c
Source dataset
uspto-grants-2005_04
Patent number
US06878713B2

Reaction notes

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