Hydrochloric Acid → 4-Quinolone-3-carboxylic acid
Reaction equation
[O:1]=[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]=[CH:4][CH:3]1[C:12]([OH:14])=[O:13].[OH-].[Na+].Cl>>[O:1]=[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[NH:5][CH:4]=[C:3]1[C:12]([OH:14])=[O:13]Participants
4
Procedure
1-Cyclopropyl-6-fluoro-8-methoxy-7-{4-amino-3-alkyl/3,3dialkyl/3,5-dialkyl-1-piperidinyl}-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid and enantiomers were prepared by hydrolysis of racemic or optically active 1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-{4-benzyloxycarbonylamino/t-butyloxycarbonylamino/ethoxycarbonylamino-3-alkyl/3,3-dialkyl/3,5-dialkyl-1-piperidinyl)-4-oxo-quinoline-3-carboxylic acid with aqueous alkali preferably aqueous sodium hydroxide or inorganic acid such as hydrochloric acid at ambient temperature for 2-12 hr.
Sources & evidence
- ORD record
- ord-e173038b4d6540e59ba4a5a2e2af7b84
- Source dataset
- uspto-grants-2005_04
- Patent number
- US06878713B2
Reaction notes
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