HCID 53951389, compound → HCID 53803790, compound

HRID 1814957Notes

Reaction equation

HRID 1814957 reaction equation
[N:1]([C@H:4]([CH3:22])[CH2:5][CH2:6][CH2:7][CH2:8][N:9]1[C:18](=[O:19])[C:17]2[N:16]([CH3:20])[CH:15]=[N:14][C:13]=2[N:12]([CH3:21])[C:10]1=[O:11])=[N+]=[N-].[H][H]>C(O)C.[Pd]>[NH2:1][C@H:4]([CH3:22])[CH2:5][CH2:6][CH2:7][CH2:8][N:9]1[C:18](=[O:19])[C:17]2[N:16]([CH3:20])[CH:15]=[N:14][C:13]=2[N:12]([CH3:21])[C:10]1=[O:11]

Participants

5

Reactant 2

HCID 53951389HCID 53951389, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 53803790HCID 53803790, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A solution of the (R)-1-(5-azidohexyl)-3,7-dimethylxanthine (620 mg) in ethanol (25 ml) was hydrogenated at 70 psi of hydrogen gas in presence of 10% palladium on carbon (150 mg) for 12 hours. After filtration to remove the catalyst, the filtrate was concentrated under reduced pressure to provide (R)-1-(5-aminohexyl)-3,7-dimethylxanthine.

Workup

  1. filtrationAfter filtration
  2. customto remove the catalyst
  3. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-05f1241752ae45dfac9c0a24fd76ffc9
Source dataset
uspto-grants-2005_04
Patent number
US06878715B1

Reaction notes

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