HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 2-(Piperidin-4-yloxy)pyridine dihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 1-Boc-4-(2-pyridyloxy)piperidine | HCID 21906039 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 2-(Piperidin-4-yloxy)pyridine dihydrochloride | HCID 14674154 | 90% |
Reaction Steps
1-t-Butoxycarbonyl-4-(2-pyridoxy)piperidine (6.5 g) was treated with a solution of hydrogen chloride in ethyl acetate (110 mL) for 7 h, and the mixture evaporated to give 4-(2-pyridoxy)piperidine dihydrochloride (7.4 g, 90%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06878725B2 |
| Source dataset | uspto-grants-2005_04 |
| ORD ID | ord-362d9ac1ab994bb2b5f3eb38714c3422 |
| Source note | uspto-grants-2005_04 |