Hydrochloric Acid → 2-(Piperidin-4-yloxy)pyridine dihydrochloride

HRID 1815062Notes

Reaction equation

HRID 1815062 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([O:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][N:16]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:21]>C(OCC)(=O)C>[ClH:21].[ClH:21].[N:16]1[CH:17]=[CH:18][CH:19]=[CH:20][C:15]=1[O:14][CH:11]1[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 219060391-Boc-4-(2-pyridyloxy)piperidine

Product 1

HCID 146741542-(Piperidin-4-yloxy)pyridine dihydrochlorideYield 90%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

1-t-Butoxycarbonyl-4-(2-pyridoxy)piperidine (6.5 g) was treated with a solution of hydrogen chloride in ethyl acetate (110 mL) for 7 h, and the mixture evaporated to give 4-(2-pyridoxy)piperidine dihydrochloride (7.4 g, 90%).

Workup

  1. customthe mixture evaporated

Sources & evidence

ORD record
ord-362d9ac1ab994bb2b5f3eb38714c3422
Source dataset
uspto-grants-2005_04
Patent number
US06878725B2

Reaction notes

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