Ethanol → 4-(Piperidin-4-yloxy)pyridine dihydrochloride

HRID 1815067Notes

Reaction equation

HRID 1815067 reaction equation
C([N:8]1[CH2:13][CH2:12][CH:11]([O:14][C:15]2[CH:20]=[CH:19][N:18]=[CH:17][CH:16]=2)[CH2:10][CH2:9]1)(OC(C)(C)C)=O.[ClH:21].Cl.N1C=CC=CC=1OC1CCNCC1.C(O)C>C(OCC)C>[ClH:21].[ClH:21].[N:8]1[CH:13]=[CH:12][C:11]([O:14][CH:15]2[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]2)=[CH:10][CH:9]=1

Participants

5

Reactant 3

HCID 702EthanolHCID 146741542-(Piperidin-4-yloxy)pyridine dihydrochlorideHCID 21906087Tert-butyl 4-(pyridin-4-yloxy)piperidine-1-carboxylate

Product 1

HCID 177497874-(Piperidin-4-yloxy)pyridine dihydrochloride

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

Prepared from 1-Boc-4-(pyridin-4-yloxy)piperidine using methods substantially equivalent to those described for the synthesis of 4-(pyridin-2-yloxy)piperidine dihydrochloride, using ethanol in place of ethyl acetate. The product was isolated by trituration with diethyl ether.

Sources & evidence

ORD record
ord-56e35732005544949c8a319a0da8f263
Source dataset
uspto-grants-2005_04
Patent number
US06878725B2

Reaction notes

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