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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1815067Generated: October 31, 2026

Ethanol → 4-(Piperidin-4-yloxy)pyridine dihydrochloride

https://huagongshe.com/reaction/1815067

Reaction equation

Participants

RoleNameHCIDCharge
ReactantEthanolHCID 702—
Reactant2-(Piperidin-4-yloxy)pyridine dihydrochlorideHCID 14674154—
ReactantTert-butyl 4-(pyridin-4-yloxy)piperidine-1-carboxylateHCID 21906087—
SolventDiethyl EtherHCID 3283—
Product4-(Piperidin-4-yloxy)pyridine dihydrochlorideHCID 17749787—

Reaction Steps

Prepared from 1-Boc-4-(pyridin-4-yloxy)piperidine using methods substantially equivalent to those described for the synthesis of 4-(pyridin-2-yloxy)piperidine dihydrochloride, using ethanol in place of ethyl acetate. The product was isolated by trituration with diethyl ether.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06878725B2
Source datasetuspto-grants-2005_04
ORD IDord-56e35732005544949c8a319a0da8f263
Source noteuspto-grants-2005_04