Hydrochloric Acid → C-(2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-4-yl)-methylamine HCl salt

HRID 1815171Notes

Reaction equation

C([N:4]1[C:8]2=[N:9][CH:10]=[CH:11][C:12]([CH2:13][NH:14]C(=O)C)=[C:7]2[CH2:6][CH2:5]1)(=O)C.[ClH:18]>CCO>[ClH:18].[NH:4]1[C:8]2=[N:9][CH:10]=[CH:11][C:12]([CH2:13][NH2:14])=[C:7]2[CH2:6][CH2:5]1

Participants

Conditions

Temperature: 70 °C

Procedure

A mixture of N-(1-acetyl-2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-4-ylmethyl)-acetamide (0.50 g), HCl (conc., 3 mL) and EtOH (12 mL) was heated to 70° C. for overnight. Additional 3 mL of conc. HCl was added to the reaction and the heating was continued for 3 more days. Solvent was evaporated to give a white residue as crude C-(2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-4-yl)-methylamine HCl salt, which was used without further purification.

Workup

customSolvent was evaporated

Sources & evidence

ORD record: ord-5f9d4b5ac3fc4687990a32387b230470
Source dataset: uspto-grants-2005_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06878714B2

Reaction notes

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