Ethylenediamine → N~1~-(Pyridin-2-yl)ethane-1,2-diamine

HRID 1815192Notes

Reaction equation

[CH2:1]([NH2:4])[CH2:2][NH2:3].F[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][N:7]=1>>[N:7]1[CH:8]=[CH:9][CH:10]=[CH:11][C:6]=1[NH:3][CH2:2][CH2:1][NH2:4]

Participants

Reactant 2

HCID 3301Ethylenediamine

HCID 97462-Fluoropyridine

Product 1

HCID 410428N~1~-(Pyridin-2-yl)ethane-1,2-diamine

Procedure

Ethylenediamine (6 g, 0.1 mol) and 2-fluoropyridine (10 g, 0.1 mol) were heated neat at 120° C. overnight. The reaction was cooled and the residue was used in next step without further purification.

Workup

temperatureThe reaction was cooled
customthe residue was used in next step without further purification

Sources & evidence

ORD record: ord-fe9552d59bb946a194e10bc3b8441305
Source dataset: uspto-grants-2005_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06878714B2

Reaction notes

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