Piperidine → HCID 67281560, compound

HRID 1815347Notes

Reaction equation

HRID 1815347 reaction equation
C[C:2]1([S:12]([NH:15][CH3:16])(=[O:14])=[O:13])[CH:10]=[CH:9][C:8]2[NH:7][C:6](=[O:11])[CH2:5][C:4]=2[CH2:3]1.[CH2:17]([O:19][C:20](=[O:33])[CH2:21][NH:22][C:23]([C:25]1[C:29]([CH3:30])=[C:28]([CH:31]=O)[NH:27][CH:26]=1)=[O:24])[CH3:18].N1CCCC[CH2:35]1>C(O)C>[CH2:17]([O:19][C:20](=[O:33])[CH2:21][NH:22][C:23]([C:25]1[C:29]([CH3:30])=[C:28]([CH:31]=[C:5]2[C:4]3[C:8](=[CH:9][CH:10]=[C:2]([S:12](=[O:13])(=[O:14])[NH:15][CH3:16])[C:3]=3[CH3:35])[NH:7][C:6]2=[O:11])[NH:27][CH:26]=1)=[O:24])[CH3:18]

Participants

5

Reactant 3

HCID 8082PiperidineHCID 85786887HCID 85786887, compoundHCID 867596395-Methyl-5-methylaminosulfonyl-2-oxindole

Product 1

HCID 67281560HCID 67281560, compoundYield 52%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

5-Methyl-5-methylaminosulfonyl-2-oxindole (50 mg, 0.21 mmol) was condensed with [(5-formyl-4-methyl-1H-pyrrole-3-carbonyl)-amino]-acetic acid ethyl ester (100 mg, 0.42 mmol) and piperidine (0.1 mL) in ethanol (2 mL) to give 50 mg (52%) of the title compound.

Sources & evidence

ORD record
ord-de35b53d80434f36ab580cda43003eb3
Source dataset
uspto-grants-2005_04
Patent number
US06878733B1

Reaction notes

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