反应详情

0.155 ml of anhydrous pyridine is added to a solution of 1.71 mmol of p-nitrophenyl chloroformate in 5 ml of anhydrous dichloromethane. A white precipitate is formed in the reaction mixture. A solution of 0.502 mmol of the compound obtained in Step 1 in 5 ml of dichloromethane is then added dropwise under argon. Stirring is carried out for 45 minutes at ambient temperature, then 15 ml of water are poured into the reaction mixture. The organic phase is washed with water, dried over MgSO4, filtered and concentrated under recued pressure. Chromatography on silica gel (cyclohexane/ethyl acetate: 4/1) enables the expected product to be isolated.

1. customA white precipitate is formed in the reaction mixture
2. washThe organic phase is washed with water
3. dry with materialdried over MgSO4
4. filtrationfiltered
5. concentrationconcentrated under recued pressure
6. customto be isolated