反应详情

210 mg of 4-(3,3-Difluoro-cyclobutylamino)-5-methanesulfonyl-2-methyl-benzoic acid methyl ester were dissolved using 10 ml of dioxane, and 0.47 ml of a 2N aqueous NaOHsolution was added. The mixture was stirred for 18 h at ambient temperature. Afterwards, the solvents were removed in vacuo. The residue was then taken up using 10 ml of water. The pH was adjusted to pH=2 using an aqueous HClsolution and extracted three times using 20 ml of EE each time. The organic layer was dried over MgSO4 and the solvent removed in vacuo. Yield: 196 mg of an amorphous solid.

1. additionwas added
2. customAfterwards, the solvents were removed in vacuo
3. extractionextracted three times
4. dry with materialThe organic layer was dried over MgSO4
5. customthe solvent removed in vacuo