4-(3,3-Difluoro-cyclobutylamino)-5-methanesulfonyl-2-methyl-benzoic acid methyl ester → 4-(3,3-Difluoro-cyclobutylamino)-5-methanesulfonyl-2-methyl-benzoic acid

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Reaction Steps

210 mg of 4-(3,3-Difluoro-cyclobutylamino)-5-methanesulfonyl-2-methyl-benzoic acid methyl ester were dissolved using 10 ml of dioxane, and 0.47 ml of a 2N aqueous NaOHsolution was added. The mixture was stirred for 18 h at ambient temperature. Afterwards, the solvents were removed in vacuo. The residue was then taken up using 10 ml of water. The pH was adjusted to pH=2 using an aqueous HClsolution and extracted three times using 20 ml of EE each time. The organic layer was dried over MgSO4 and the solvent removed in vacuo. Yield: 196 mg of an amorphous solid.

Provenance & Evidence