Sodium Hydroxide → HCID 74087995, compound

HRID 1815597Notes

Reaction equation

HRID 1815597 reaction equation
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([C:7](=[N:13][OH:14])[C:8]([O:10]CC)=[O:9])[N:6]=1.[OH-:15].[Na+:16]>C(O)C>[OH2:9].[OH2:15].[Na+:16].[NH2:1][C:2]1[S:3][CH:4]=[C:5]([C:7](=[N:13][OH:14])[C:8]([O-:10])=[O:9])[N:6]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 6738988Ethyl 2-(2-aminothiazole-4-yl)-2-hydroxyiminoacetate

Product 1

HCID 74087995HCID 74087995, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
45 °C

Procedure

Ethyl 2-(2-aminothiazole-4-yl)-2-hydroxyiminoacetate (syn-isomer) (24.0 g) was suspended in ethanol (26 ml), and 1N aqueous sodium hydroxide (125 ml) was added dropwise thereto for one hour under stirring at 45° C. After the dropwise addition, the mixture was stirred for two hours at the same temperature. The reaction mixture was cooled to 5° C. and stirred for one hour. The precipitate was filtered and collected, washed with ethanol, and dried under vacuum to obtain 2-(2-aminothiazole-4-yl)-2-hydroxyiminoacetate sodium dihydrate (syn-isomer) (24.6 g).

Workup

  1. additionAfter the dropwise addition
  2. stirringthe mixture was stirred for two hours at the same temperature
  3. temperatureThe reaction mixture was cooled to 5° C.
  4. stirringstirred for one hour
  5. filtrationThe precipitate was filtered
  6. customcollected
  7. washwashed with ethanol
  8. customdried under vacuum

Sources & evidence

ORD record
ord-fc8b386caffc437e94d6f68be2dea86d
Source dataset
uspto-grants-2005_04
Patent number
US06878827B2

Reaction notes

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