Sodium Hydroxide → HCID 74087995, compound

Participants

Reaction Conditions

Reaction Steps

Ethyl 2-(2-aminothiazole-4-yl)-2-hydroxyiminoacetate (syn-isomer) (24.0 g) was suspended in ethanol (26 ml), and 1N aqueous sodium hydroxide (125 ml) was added dropwise thereto for one hour under stirring at 45° C. After the dropwise addition, the mixture was stirred for two hours at the same temperature. The reaction mixture was cooled to 5° C. and stirred for one hour. The precipitate was filtered and collected, washed with ethanol, and dried under vacuum to obtain 2-(2-aminothiazole-4-yl)-2-hydroxyiminoacetate sodium dihydrate (syn-isomer) (24.6 g).

Provenance & Evidence