Iodoethane → N-tert-Butyl-1-ethylcyclopropane-1-sulfonamide

HRID 1815702Notes

Reaction equation

HRID 1815702 reaction equation
[C:1]([NH:5][S:6]([CH2:9][CH2:10][CH2:11]Cl)(=[O:8])=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH2:13](I)[CH3:14].C(NS(C1(C)CC1)(=O)=O)(C)(C)C>>[C:1]([NH:5][S:6]([C:9]1([CH2:13][CH3:14])[CH2:11][CH2:10]1)(=[O:8])=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

4

Reactant 3

HCID 6340IodoethaneHCID 11701296N-tert-butyl-3-chloropropane-1-sulfonamideHCID 21889792N-tert-butyl-1-methylcyclopropane-1-sulfonamide

Product 1

HCID 22499355N-tert-Butyl-1-ethylcyclopropane-1-sulfonamide

Procedure

Step 28a) This compound was prepared form N-tert-Butyl-(3-chloro) propylsulfonamide (59 g, 276 mmol) and ethyl iodide (86.11 g, 552 mmol) according to the procedure of Steps 3Ib-3Ic (Example 2) described in the synthesis of N-tert-Butyl-(1-methyl) cyclopropylsulfonamide. The compound was used as crude: 1H NMR (CHLOROFORM-D) □ ppm 0.82 (m, 2H), 0.99 (t, J=7.48 Hz, 3H), 1.33 (m, 11H), 1.92 (q, J=7.53 Hz, 2H), 3.91 (s, 1H).

Sources & evidence

ORD record
ord-5f77f734f304416a9ec1feb0d88473d7
Source dataset
uspto-grants-2005_04
Patent number
US06878722B2

Reaction notes

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