Toluene → HCID 22144861, compound

HRID 1815804Notes

Reaction equation

HRID 1815804 reaction equation
[Br:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[O:9][CH2:10][CH:11]=[CH:12][CH2:13]C.C1(C)C=CC=CC=1>O>[CH2:12]([C:11]1[C:4]2[CH:5]=[C:6]([F:8])[CH:7]=[C:2]([Br:1])[C:3]=2[O:9][CH:10]=1)[CH3:13]

Participants

4

Reactant 2

HCID 1140TolueneHCID 69627321HCID 69627321, compound

Product 1

HCID 22144861HCID 22144861, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Beginning with pent-2-en-1-yl 2-bromo-4-fluorophenyl ether, the title compound was prepared essentially as described in Preparation XVII, except that Amberlyst 15™ resin in refluxing toluene was used in place of sulfuric acid, and water was removed by azeotropic distillation with a Dean-Stark trap.

Workup

  1. customwas removed by azeotropic distillation with a Dean-Stark trap

Sources & evidence

ORD record
ord-31e329c4268c48d18a3a38db122f0212
Source dataset
uspto-grants-2005_04
Patent number
US06881733B1

Reaction notes

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