Oxalic Acid → tert-Butyl 2-methyl-4-oxopiperidine-1-carboxylate

A solution of 5 mL (49 mMol) 4-methoxypyridine in 200 mL tetrahydrofuran was cooled to −40° C., and then 6.9 mL (55 mMol) phenyl chloroformate were added dropwise. After stirring for 15 minutes, 20 mL (60 mMol) methyl magnesium chloride (3M in tetrahydrofuran) were added dropwise and the reaction mixture was allowed to warm to room temperature. After stirring for 30 minutes, the reaction mixture was cooled to −40° C. and treated with 340 mMol potassium tert-butoxide. The reaction mixture was allowed to warm to room temperature. After stirring for 1 hour, the reaction mixture was cooled to −40° C. and was treated with 200 mL saturated aqueous oxalic acid. The reaction was warmed to 20° C. and allowed to stir for 1 hour. The mixture was extracted 2×200 mL diethyl ether. The combined organic phases were washed sequentially with 4×100 mL 0.5 N sodium hydroxide, 2×100 mL saturated aqueous sodium bicarbonate, 3×100 mL deionized water, and 100 mL saturated aqueous sodium chloride. The remaining organics were dried over magnesium sulfate and concentrated under reduced pressure. The residue was subjected to silica gel chromatography, eluting with hexanes containing 40% ethylacetate. Fractions containing product were combined and concentrated under reduced pressure to provide 4.9 gm (47%) 1-(tert-butoxycarbonyl)-2-methyl-4-oxopiperidine.

1. stirringAfter stirring for 30 minutes
2. temperaturethe reaction mixture was cooled to −40° C.
3. temperatureto warm to room temperature
4. stirringAfter stirring for 1 hour
5. temperaturethe reaction mixture was cooled to −40° C.
6. temperatureThe reaction was warmed to 20° C.
7. stirringto stir for 1 hour
8. extractionThe mixture was extracted 2×200 mL diethyl ether
9. washThe combined organic phases were washed sequentially with 4×100 mL 0.5 N sodium hydroxide, 2×100 mL saturated aqueous sodium bicarbonate, 3×100 mL
10. dry with materialThe remaining organics were dried over magnesium sulfate
11. concentrationconcentrated under reduced pressure
12. washeluting with hexanes containing 40% ethylacetate
13. additionFractions containing product
14. concentrationconcentrated under reduced pressure

ORD record

ord-5d53d75379d44726b91b2a0168223c0f

Source dataset

uspto-grants-2005_04

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06881733B1