1-Benzyl-3-methyl-4-piperidone → HCID 22495572, compound

HRID 1815843Notes

Reaction equation

HRID 1815843 reaction equation
[F:1][C:2]1[CH:10]=[CH:9][C:5]2[CH:6]=[CH:7][O:8][C:4]=2[C:3]=1Br.[CH2:12]([N:19]1[CH2:24][CH2:23][C:22](=[O:25])[CH:21]([CH3:26])[CH2:20]1)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>>[CH2:12]([N:19]1[CH2:24][CH2:23][C:22]([OH:25])([C:3]2[C:4]3[O:8][CH:7]=[CH:6][C:5]=3[CH:9]=[CH:10][C:2]=2[F:1])[CH:21]([CH3:26])[CH2:20]1)[C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=1

Participants

3

Reactant 2

HCID 5609651-Benzyl-3-methyl-4-piperidoneHCID 221449297-Bromo-6-fluoro-1-benzofuran

Product 1

HCID 22495572HCID 22495572, compoundYield 59.3%

Procedure

Beginning with 5.22 gm (24.3 mMol) 6-fluoro-7-bromobenzofuran and 5.19 gm (25.5 mMol) 1-benzyl-3-methyl-4-oxopiperidine, 4.89 gm (59%) of the desired compound were prepared as a mixture of cis- and trans-isomers, essentially as described in EXAMPLE 3.

Sources & evidence

ORD record
ord-6249c11d38cb4dfdb0a156aecefb30b5
Source dataset
uspto-grants-2005_04
Patent number
US06881733B1

Reaction notes

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