Tributylstannane → HCID 69745147, compound

HRID 1815859Notes

Reaction equation

HRID 1815859 reaction equation
[CH2:1]([N:8]1[CH2:13][CH2:12][C:11](OC(=O)C(C)=O)([C:14]2[C:22]3[O:21][C:20]([CH3:23])=[CH:19][C:18]=3[CH:17]=[CH:16][CH:15]=2)[CH:10]([CH3:30])[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C([SnH](CCCC)CCCC)CCC>>[CH2:1]([N:8]1[CH2:13][CH2:12][C@H:11]([C:14]2[C:22]3[O:21][C:20]([CH3:23])=[CH:19][C:18]=3[CH:17]=[CH:16][CH:15]=2)[C@H:10]([CH3:30])[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 5948TributylstannaneHCID 22495558HCID 22495558, compound

Product 1

HCID 69745147HCID 69745147, compound

Procedure

Beginning with 1.06 gm (3.16 mMol) cis-1-benzyl-3-methyl-4-hydroxy-4-(2-methylbenzofur-7-yl)piperidine, 1-benzyl-3-methyl-4-(methyl oxoacetoxy)-4-(2-methylbenzofur-7-yl)piperidine was prepared essentially as described in EXAMPLE 16. This material was treated with tri(n-butyl)tin hydride essentially as described in EXAMPLE 16 to provide the desired compound.

Workup

  1. customwas prepared essentially

Sources & evidence

ORD record
ord-eac2b90fbf8c458383897aae964daca5
Source dataset
uspto-grants-2005_04
Patent number
US06881733B1

Reaction notes

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