Tributylstannane → HCID 69744907, compound

HRID 1815869Notes

Reaction equation

HRID 1815869 reaction equation
[CH2:1]([N:8]1[CH2:13][CH2:12][C:11](O)([C:14]2[C:22]3[O:21][CH:20]=[CH:19][C:18]=3[CH:17]=[C:16]([F:23])[C:15]=2[F:24])[CH:10]([CH3:26])[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(N1CCC(OC(=O)C(C)=O)(C2C3OC=CC=3C=C(F)C=2F)C(C)C1)C1C=CC=CC=1.C([SnH](CCCC)CCCC)CCC>>[CH2:1]([N:8]1[CH2:13][CH2:12][C@H:11]([C:14]2[C:22]3[O:21][CH:20]=[CH:19][C:18]=3[CH:17]=[C:16]([F:23])[C:15]=2[F:24])[C@H:10]([CH3:26])[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 5948TributylstannaneHCID 22495677HCID 22495677, compoundHCID 22495727HCID 22495727, compound

Product 1

HCID 69744907HCID 69744907, compoundYield 32.4%

Procedure

Beginning with 0.75 gm (2.08 mMol) 1-benzyl-3-methyl-4-hydroxy-4-(5,6-difluorobenzofur-7-yl)piperidine, 1-benzyl-3-methyl-4-(methyl oxoacetoxy)-4-(5,6-difluorobenzofur-7-yl)piperidine was prepared essentially as described in EXAMPLE 16. This material was treated with tri(n-butyl)tin hydride essentially as described in EXAMPLE 16 to prepare 0.23 gm (32%) of the desired compound.

Workup

  1. customwas prepared essentially

Sources & evidence

ORD record
ord-2042b56d36fc49ea8187d86d6c9ab558
Source dataset
uspto-grants-2005_04
Patent number
US06881733B1

Reaction notes

Loading…