1-Benzyl-3,3-dimethylpiperidin-4-one → 3,3-Dimethyl-4-(5-chlorobenzofur-7-yl)-1,2,3,6-tetrahydropyridine hydrochloride

HRID 1815873Notes

Reaction equation

HRID 1815873 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4](Br)[C:5]2[O:9][CH:8]=[CH:7][C:6]=2[CH:10]=1.C([N:19]1[CH2:24][CH2:23][C:22](=O)[C:21]([CH3:27])([CH3:26])[CH2:20]1)C1C=CC=CC=1>>[ClH:1].[CH3:26][C:21]1([CH3:27])[C:22]([C:4]2[C:5]3[O:9][CH:8]=[CH:7][C:6]=3[CH:10]=[C:2]([Cl:1])[CH:3]=2)=[CH:23][CH2:24][NH:19][CH2:20]1

Participants

3

Reactant 2

HCID 97944131-Benzyl-3,3-dimethylpiperidin-4-oneHCID 221447207-Bromo-5-chloro-1-benzofuran

Product 1

HCID 224956403,3-Dimethyl-4-(5-chlorobenzofur-7-yl)-1,2,3,6-tetrahydropyridine hydrochloride

Procedure

Beginning with 5-chloro-7-bromobenzofuran and 1-benzyl-3,3-dimethyl-4-oxopiperidine, 0.29 gm of the title compound were prepared essentially as described in EXAMPLE 5.

Sources & evidence

ORD record
ord-d09794c6975249e4a887ed19f490ab8c
Source dataset
uspto-grants-2005_04
Patent number
US06881733B1

Reaction notes

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