反应详情

温度

100 °C

To a slurry of (4-chloro-[1,3,5]triazin-2-yl)-(1-pyridin-2-ylmethyl-1H-indazol-5-yl)-amine (Step 3) (90.0 mg, 0.266 mmol) in IpOH (3.0 ml) was added DIEA (0.07 mL, 0.40 mmol) and N-(3-aminophenyl)acrylamide (47.5 mg, 0.293 mmol). The mix was heated at 100° C. for 18 h. The solution was cooled to RT. A precipitate fell out of solution, was filtered off and dried under reduced pressure to give N-{3-[4-(1-pyridin-2-ylmethyl-1H-indazol-5-ylamino)-[1,3,5]triazin-2-ylamino]-phenyl}-acrylamide: MS m/z=464[M+H]+. Calc'd for C25H21N9O: 463.19.

1. temperatureThe solution was cooled to RT
2. filtrationwas filtered off
3. customdried under reduced pressure