反应详情

温度

100 °C

To a slurry of (3-chlorophenyl)-(4-chloro-[1,3,5]triazin-2-yl)amine (Step 1) (80.0 mg, 0.332 mmol) in IpOH (2.5 ml) was added DIEA (0.087 mL, 0.50 mmol) and N-(3-aminophenyl)acrylamide (59.2 mg, 0.365 mmol). The mix was heated at 100° C. for 18 h. The solution was then cooled to RT. A precipitate fell out of solution, was filtered off and dried under reduced pressure to give N-{3-[4-(3-chlorophenylamino)-[1,3,5]triazin-2-ylamino]-phenyl}-acrylamide: MS m/z=367[M+H]. Calc'd for C18H15ClN6O: 366.10.

1. temperatureThe solution was then cooled to RT
2. filtrationwas filtered off
3. customdried under reduced pressure