反应详情

温度

100 °C

To a slurry of 7-chloro-1-(4-chloro-[1,3,5]triazin-2-yl)-1,2,3,4-tetrahydro-quinoline (Step 2)(70 mg, 0.249 mmol) in IpOH (2.0 ml) was added DIEA (0.20 mL, 1.15 mmol) and N-(3-aminophenyl)acrylamide (100 mg, 0.192 mmol). The heated at 100° C. for 18 h, then cooled to RT. The organics were concentrated under reduced pressure then purified by column chromatography (elution with CH2Cl2 followed by 99:1 CH2Cl2/MeOH followed by 97:3 CH2Cl2/MeOH) to give N-{3-[4-(7-chloro-3,4-dihydro-2H-quinolin-1-yl)-[1,3,5]triazin-2-ylamino]-phenyl}-acrylamide: MS m/z=407 [M+H]+. Calc'd for C21H19ClN6O: 406.13.

1. temperaturecooled to RT
2. concentrationThe organics were concentrated under reduced pressure
3. customthen purified by column chromatography (elution with CH2Cl2 followed by 99:1 CH2Cl2/MeOH followed by 97:3 CH2Cl2/MeOH)