反应详情

A suspension of the product from Step C (3.66 g, 9.51 mmol), potassium carbonate (1.92 g, 1.46 mmol), and epibromohydrine (1.32 mL, 1.60 mmol) in acetone (200 mL) was heated at reflux for 30 h. The solid was removed by filtration and the filtrate was concentrated to an oil that was purified by chromatography (silica, 2% to 10% EtOAc/hexane) to afford an oil (3.33 g, 79%): LC/MS (+APCI) m/z 441, 443 (M+H).

1. temperaturewas heated
2. temperatureat reflux for 30 h
3. customThe solid was removed by filtration
4. concentrationthe filtrate was concentrated to an oil that
5. customwas purified by chromatography (silica, 2% to 10% EtOAc/hexane)