Methanol → HCID 12985380, compound

HRID 1815977Notes

Reaction equation

HRID 1815977 reaction equation
[N:1]([CH:4]1[C:16]2[C:8](=[CH:9][CH:10]=[C:11]3[C:15]=2[N:14]([CH2:17][C@@H:18]([NH:20]C(=O)OCC2C=CC=CC=2)[CH3:19])[N:13]=[CH:12]3)[O:7][CH2:6][CH:5]1Br)=[N+]=[N-].C[OH:33]>[Pd]>[NH2:1][CH:4]1[C:16]2[C:8](=[CH:9][CH:10]=[C:11]3[C:15]=2[N:14]([CH2:17][C@@H:18]([NH2:20])[CH3:19])[N:13]=[CH:12]3)[O:7][CH2:6][CH:5]1[OH:33]

Participants

4

Reactant 2

HCID 887MethanolHCID 86759657HCID 86759657, compound

Product 1

HCID 12985380HCID 12985380, compoundYield 96%

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

The product from step B (0.26 g, 0.30 mmol) and Pd/C (10%, 0.026 g) were mixed with methanol (5 mL) and placed under a hydrogen atmosphere for 18 h. The mixture was filtered and evaporated to give a yellowish solid (0.155 g, 96%): mp 84-88° C.; LC/MS (+APCI) m/z 263 (M+H).

Workup

  1. filtrationThe mixture was filtered
  2. customevaporated

Sources & evidence

ORD record
ord-4f19b10671164383a40aa7aaf38257aa
Source dataset
uspto-grants-2005_04
Patent number
US06881749B2

Reaction notes

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