Hydrochloric Acid → HCID 131724840, compound

HRID 1816064Notes

Reaction equation

HRID 1816064 reaction equation
Cl.[Cl:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][CH2:10][NH:11]C(=O)OC(C)(C)C)=[CH:5][C:4]=1[C:19]([NH:21][CH2:22][C:23]12[CH2:32][CH:27]3[CH2:28][CH:29]([CH2:31][CH:25]([CH2:26]3)[CH2:24]1)[CH2:30]2)=[O:20]>CO.ClCCl>[ClH:2].[NH2:11][CH2:10][CH2:9][C:6]1[CH:7]=[CH:8][C:3]([Cl:2])=[C:4]([CH:5]=1)[C:19]([NH:21][CH2:22][C:23]12[CH2:30][CH:29]3[CH2:31][CH:25]([CH2:26][CH:27]([CH2:28]3)[CH2:32]1)[CH2:24]2)=[O:20]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86596765HCID 86596765, compound

Product 1

HCID 131724840HCID 131724840, compoundYield 196.1%

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

Hydrochloric acid (4M in 1,4-dioxane, 3.0 ml) was added to a solution of [2-[4-chloro-3-[[(tricyclo[3.3.1.13,7]dec-1-ylmethyl)amino]carbonyl]phenyl]ethyl]carbamic acid, 1,1-dimethylethyl ester (2.2 g, Example 30b) in methanol/dichloromethane (1:1) (50 ml). After 24 h the solvent was evaporated to leave the title compound as a foam (1.85 g).

Workup

  1. customAfter 24 h the solvent was evaporated

Sources & evidence

ORD record
ord-3c88f84eb5df4d799393a2aec7a038f6
Source dataset
uspto-grants-2005_04
Patent number
US06881754B2

Reaction notes

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