反应详情

2-Aminothiophenol (5.0 g, 40 mmol, Lancaster Synthesis Inc., Windham, N.H.) was stirred in dry ethanol (100 mL) and cooled in an ice bath. Potassium t-butoxide (4.5 g, 40 mmol) was added portionwise over 15 minutes and the mixture was stirred for an additional 45 minutes. Ethyl iodide (3.3 mL, 41 mmol) was added dropwise over 15 minutes and the mixture was allowed to warm to room temperature and stirred for 45 minutes. The mixture was filtered and the filtrate evaporated to dryness in vacuo. The resulting residue was treated with dichloromethane (100 mL) and filtered and the resulting filtrate was evaporated to dryness in vacuo to give 2-(ethylthio)aniline (5.2 g).

1. temperaturecooled in an ice bath
2. stirringstirred for 45 minutes
3. filtrationThe mixture was filtered
4. customthe filtrate evaporated to dryness in vacuo
5. additionThe resulting residue was treated with dichloromethane (100 mL)
6. filtrationfiltered
7. customthe resulting filtrate was evaporated to dryness in vacuo