Butylamine → HCID 22493277, compound

HRID 1816262Notes

Reaction equation

HRID 1816262 reaction equation
[NH2:1][C:2]1[CH:14]=[CH:13][C:12]([F:15])=[CH:11][C:3]=1[C:4]([NH:6][CH2:7][CH2:8][CH2:9][CH3:10])=[O:5].[CH2:16]([NH2:20])[CH2:17]CC.FC1C=[CH:24][C:25]2[NH:30]C(=O)OC(=O)C=2C=1>>[CH2:7]([NH:6][C:4](=[O:5])[C:3]1[CH:11]=[C:12]([F:15])[CH:13]=[CH:14][C:2]=1[NH:1][CH2:24][C:25]1[NH:30][CH2:17][CH2:16][N:20]=1)[CH2:8][CH2:9][CH3:10]

Participants

4

Reactant 3

HCID 8007ButylamineHCID 2885605-Fluoroisatoic anhydrideHCID 22493368HCID 22493368, compound

Product 1

HCID 22493277HCID 22493277, compound

Procedure

2-Amino-N-butyl-5-fluorobenzamide (prepared from butylamine and 6-fluoro-2H-3,1-benzoxazine-2,4(1H)-dione using the methods described in Example 17) and CMI were reacted using conditions described in the general procedure for CMI coupling to give N-butyl-2-[(4,5-dihydro-1H-imidazol-2-ylmethyl)amino]-5-fluorobenzamide, isolated as the hydrochloride salt.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-bbed3f4cec5c48428c45841328606d76
Source dataset
uspto-grants-2005_04
Patent number
US06884801B1

Reaction notes

Loading…