Cyclopropylamine → HCID 22493363, compound

HRID 1816263Notes

Reaction equation

HRID 1816263 reaction equation
[NH2:1][C:2]1[CH:13]=[CH:12][C:11]([F:14])=[CH:10][C:3]=1[C:4]([NH:6][CH:7]1[CH2:9][CH2:8]1)=[O:5].[CH:15]1([NH2:18])[CH2:17]C1.FC1C=[CH:22][C:23]2[NH:28]C(=O)OC(=O)C=2C=1>>[CH:7]1([NH:6][C:4](=[O:5])[C:3]2[CH:10]=[C:11]([F:14])[CH:12]=[CH:13][C:2]=2[NH:1][CH2:17][C:15]2[NH:18][CH2:22][CH2:23][N:28]=2)[CH2:9][CH2:8]1

Participants

4

Reactant 3

HCID 69828CyclopropylamineHCID 2885605-Fluoroisatoic anhydrideHCID 22493342HCID 22493342, compound

Product 1

HCID 22493363HCID 22493363, compound

Procedure

2-Amino-N-cyclopropyl-5-fluorobenzamide (prepared from cyclopropylamine and 6-fluoro-2H-3,1-benzoxazine-2,4(1H)-dione using the methods described in Example 17) and CMI were reacted using conditions described in the general procedure for CMI coupling to give N-cyclopropyl-2-[(4,5-dihydro-1H-imidazol-2-ylmethyl)amino]-5-fluorobenzamide.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-d3d49a7eed54407badfd42516d06d064
Source dataset
uspto-grants-2005_04
Patent number
US06884801B1

Reaction notes

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