Cyclopropylamine → HCID 22493311, compound

HRID 1816264Notes

Reaction equation

HRID 1816264 reaction equation
[NH2:1][C:2]1[CH:13]=[CH:12][CH:11]=[C:10]([CH3:14])[C:3]=1[C:4]([NH:6][CH:7]1[CH2:9][CH2:8]1)=[O:5].[CH:15]1([NH2:18])[CH2:17]C1.CC1C2C(=O)OC(=O)[NH:29][C:24]=2[CH:23]=CC=1>>[CH:7]1([NH:6][C:4](=[O:5])[C:3]2[C:10]([CH3:14])=[CH:11][CH:12]=[CH:13][C:2]=2[NH:1][CH2:17][C:15]2[NH:18][CH2:23][CH2:24][N:29]=2)[CH2:8][CH2:9]1

Participants

4

Reactant 3

HCID 69828CyclopropylamineHCID 104875225-methyl-2,4-dihydro-1H-3,1-benzoxazine-2,4-dioneHCID 16795175HCID 16795175, compound

Product 1

HCID 22493311HCID 22493311, compound

Procedure

2-Amino-N-cyclopropyl-6-methylbenzamide (prepared from cyclopropylamine and 5-methyl-2H-3,1-benzoxazine-2,4(1H)-dione using the methods described in Example 17) and CMI were reacted using conditions described in the general procedure for CMI coupling to give N-cyclopropyl-2-[(4,5-dihydro-1H-imidazol-2-ylmethyl)amino]-6-methylbenzamide.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-738d21dabbdf45b38832a0d19cf8ebd1
Source dataset
uspto-grants-2005_04
Patent number
US06884801B1

Reaction notes

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