Aniline → HCID 54077451, compound

HRID 1816276Notes

Reaction equation

HRID 1816276 reaction equation
[NH:1]1[CH2:5][CH2:4][N:3]=[C:2]1[CH2:6][NH:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[N:14]1[CH2:18][CH2:17][CH2:16][CH2:15]1.F[C:20]1C=CC=C[C:21]=1[N+]([O-])=O.NC1C=CC=CC=1>>[N:14]1([C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=2[NH:7][CH2:6][C:2]2[NH:1][CH2:5][CH2:4][N:3]=2)[CH:18]=[CH:17][CH:16]=[CH:15][CH:21]=[CH:20]1

Participants

4

Reactant 3

HCID 6115AnilineHCID 738951-Fluoro-2-nitrobenzeneHCID 22493417N-(4,5-dihydro-1H-imidazol-2-ylmethyl)-2-(1-pyrrolidinyl)aniline

Product 1

HCID 54077451HCID 54077451, compound

Procedure

Under conditions similar to those used for the preparation of N-(4,5-dihydro-1H-imidazol-2-ylmethyl)-2-(1-pyrrolidinyl)aniline (Example 64), hexamethyleneimine was reacted with 2-fluoronitrobenzene, the nitro group was reduced and the aniline was coupled with CMI to give 2-(1-azepinyl)-N-(4,5-dihydro-1H-imidazol-2-ylmethyl)aniline .

Sources & evidence

ORD record
ord-a862daa34cad486d98f886c27c4f7372
Source dataset
uspto-grants-2005_04
Patent number
US06884801B1

Reaction notes

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