Hydrazine → HCID 3544473, compound

HRID 1816295Notes

Reaction equation

HRID 1816295 reaction equation
C[N:2](C)[CH:3]=[C:4]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[N+:13]([O-:15])=[O:14])[CH:5]=O.[NH2:17]N>C(O)C>[N+:13]([C:8]1[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=1[C:4]1[CH:3]=[N:2][NH:17][CH:5]=1)([O-:15])=[O:14]

Participants

4

Reactant 2

HCID 9321HydrazineHCID 3557290HCID 3557290, compound

Product 1

HCID 3544473HCID 3544473, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

3-Dimethylamino-2-(2-nitrophenyl)propenal (Maybridge) in ethanol was treated with hydrazine via syringe and heated to reflux for 16 hours. Concentration in vacuo afforded crude 4-(2-nitrophenyl)pyrazole, which was reduced as in Example 64 and coupled with CMI to give the fumaric acid salt of N-(4,5-dihydro-1H-imidazol-2-ylmethyl)-2-(1H-pyrazol-4-yl)aniline.

Workup

  1. temperatureheated
  2. temperatureto reflux for 16 hours
  3. concentrationConcentration in vacuo

Sources & evidence

ORD record
ord-a633342630a0411fb0898a68c189538d
Source dataset
uspto-grants-2005_04
Patent number
US06884801B1

Reaction notes

Loading…