反应详情

温度

120 °C

2-Nitrobenzamide (12.4 g, 75 mmol) was dissolved to dimethylacetamide-dimethylacetal (25 mL ) and heated to 120° C. for 2 hours. Upon cooling, the reaction was passed through a short silica column, eluting with ethyl acetate. The crystals that formed in the collected eluent were collected by filtration and rinsed with diethyl ether to provide N-[(dimethylamino)ethylidene]-2-nitrobenzamide (7.73 g).

1. temperatureUpon cooling
2. washeluting with ethyl acetate
3. customThe crystals that formed in the collected eluent
4. filtrationwere collected by filtration
5. washrinsed with diethyl ether