反应详情

温度

80 °C

A solution of tert-butyl-4-[4-(methoxycarbonyl)phenyl]-1-piperidinecarboxylate (3.95 g) in a mixture of methanol (80 ml), THF (40 ml) and 4N sodium hydroxide (30 ml) was stirred at 80° C. for 2 hours. The reaction mixture was concentrated in vacuo. To a residue was added water (100 ml) and adjusted to pH 3 with 1N hydrochloric acid. The solution was extracted twice with a mixture of ethyl acetate (100 ml) and THF (50 ml). The extracts was dried over magnesium sulfate and evaporated in vacuo to give 4-[1-(tert-butoxycarbonyl)-4-piperidyl]benzoic acid (3.64 g).

1. concentrationThe reaction mixture was concentrated in vacuo
2. additionTo a residue was added water (100 ml)
3. extractionThe solution was extracted twice with a mixture of ethyl acetate (100 ml) and THF (50 ml)
4. dry with materialThe extracts was dried over magnesium sulfate
5. customevaporated in vacuo