Water → HCID 22492999, compound

Participants

Reaction Steps

To a solution of tert-butyl 4-[4′-(methoxycarbonyl)-1,1′-biphenyl-4-yl]-1-piperazinecarboxylate (4.5 g) and anisole (6.17 ml) in dichloromethane (45 ml) was added dropwise with stirring trifluoroacetic acid (22.5 ml) at 0° C. The mixture was then stirred for 2 hours at room temperature. To the reaction mixture was added water. The resulting precipitate was collected by filtration and washed with isopropanol and diisopropyl ether to give methyl 4′-(1-piperazinyl)-1,1′-biphenyl-4-carboxylate trifluoroacetate (4.13 g).

Provenance & Evidence