Water → HCID 22492999, compound

HRID 1816346Notes

Reaction equation

HRID 1816346 reaction equation
[CH3:1][O:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([C:11]2[CH:16]=[CH:15][C:14]([N:17]3[CH2:22][CH2:21][N:20](C(OC(C)(C)C)=O)[CH2:19][CH2:18]3)=[CH:13][CH:12]=2)=[CH:7][CH:6]=1)=[O:4].C1(OC)C=CC=CC=1.[F:38][C:39]([F:44])([F:43])[C:40]([OH:42])=[O:41].O>ClCCl>[F:38][C:39]([F:44])([F:43])[C:40]([OH:42])=[O:41].[N:17]1([C:14]2[CH:13]=[CH:12][C:11]([C:8]3[CH:9]=[CH:10][C:5]([C:3]([O:2][CH3:1])=[O:4])=[CH:6][CH:7]=3)=[CH:16][CH:15]=2)[CH2:18][CH2:19][NH:20][CH2:21][CH2:22]1

Participants

6

Reactant 4

HCID 962WaterHCID 6422Trifluoroacetic acidHCID 7519AnisoleHCID 22492871HCID 22492871, compound

Product 1

HCID 22492999HCID 22492999, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of tert-butyl 4-[4′-(methoxycarbonyl)-1,1′-biphenyl-4-yl]-1-piperazinecarboxylate (4.5 g) and anisole (6.17 ml) in dichloromethane (45 ml) was added dropwise with stirring trifluoroacetic acid (22.5 ml) at 0° C. The mixture was then stirred for 2 hours at room temperature. To the reaction mixture was added water. The resulting precipitate was collected by filtration and washed with isopropanol and diisopropyl ether to give methyl 4′-(1-piperazinyl)-1,1′-biphenyl-4-carboxylate trifluoroacetate (4.13 g).

Workup

  1. filtrationThe resulting precipitate was collected by filtration
  2. washwashed with isopropanol and diisopropyl ether

Sources & evidence

ORD record
ord-6d2939d02e894096859d7fc6e0a2fc7f
Source dataset
uspto-grants-2005_04
Patent number
US06884774B2

Reaction notes

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