反应详情

Sodium acetate (0.46 g, 5.57 mmol) in water (3 mL) was added into a mixture of (2,4-dihydroxyphenyl)(4-hydroxyphenyl)methanone (0.91 g, 3.97 mmol), hydroxylamine hydrochloride (0.36 g, 5.17 mmol), and ethanol (20 mL). The reaction mixture was refluxed for 2 days. The mixture was poured into water/brine and extracted with EtOAc. The organic extracts were dried over MgSO4. Evaporation and purification by flash chromatography CH2Cl2/EtOAc/MeOH 20/10/1) gave a white solid (0.46 g, 48% yield); MS m/e 245 (M+).

1. temperatureThe reaction mixture was refluxed for 2 days
2. extractionextracted with EtOAc
3. dry with materialThe organic extracts were dried over MgSO4
4. customEvaporation and purification by flash chromatography CH2Cl2/EtOAc/MeOH 20/10/1)