反应详情

温度

100 °C

In 110 mL of dioxane, was dissolved 7.18 g (40.3 mmol) of the compound obtained in Example 11. The resulting solution was refluxed at 100° C. for 100 minutes The refluxed solution was then cooled, and 7.42 g (44 mmol) of a 48% hydrobromic acid was added. The obtained mixture was allowed to stand at room temperature for 1 hour. Water was then added, and the obtained mixture was extracted with ethyl acetate. The resulting extract was dried with magnesium sulfate and vacuum concentrated to provide 9.04 g of 3-(bromomethyl)-5-methylbenzo[b]thiophene. The yield was 93%.

1. temperaturewas then cooled
2. extractionthe obtained mixture was extracted with ethyl acetate
3. extractionThe resulting extract
4. dry with materialwas dried with magnesium sulfate and vacuum
5. concentrationconcentrated